Journal Title
Title of Journal: Biogerontology
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Abbravation: Biogerontology
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Publisher
Springer Netherlands
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Authors: ChinYuan Hsu Jiantai Timothy Qiu YuPei Chan
Publish Date: 2016/05/26
Volume: 17, Issue: 5-6, Pages: 829-840
Abstract
Queen honeybees Apis mellifera have a much longer lifespan than worker bees Whether cellular degradation activity is involved in the longevity of queen bees is unknown In the present study cellular degradation activity was evaluated in the trophocytes and oenocytes of young and old queen bees The results indicated that i 20S proteasome activity and the size of autophagic vacuoles decreased with aging and ii there were no significant differences between young and old queen bees with regard to 20S proteasome expression or efficiency polyubiquitin aggregate expression microtubuleassociated protein 1 light chain 3II LC3II expression 70 kDa heat shock cognate protein Hsc70 expression the density of autophagic vacuoles p62/SQSTM1 expression the activity or density of lysosomes or molecular target of rapamycin expression These results indicate that cellular degradation activity maintains a youthful status in the trophocytes and oenocytes of queen bees during aging and that cellular degradation activity is involved in maintaining the longevity of queen bees
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