Biogerontology in Serbia

Authors: Nebojša Despotović P Erceg B Potić J Stojanovic D P Milosević M Davidović

Publish Date: 2010/04/18

Volume: 12, Issue: 1, Pages: 11-15

PDF Link

Abstract

Aging is caused by gradual accumulation of cell and tissue damage Accumulation of damage begins early and continues progressively throughout life resulting after several decades in the overt frailty disability and diseases associated with aging In Serbia during the last few years several different institutions participated in the investigation in the aging process 1 Changes in hormone signaling with aging—the agerelated increase in insulinemia and glucose metabolism deregulation was found to be attributed to changes in insulin signaling as demonstrated on murine models 2 Changes in immunological response in aging—along with involution of thymic lymphoepithelial tissue it has been demonstrated on a murine model that early thymocyte differentiational steps within the CD48double negative developmental stage are agesensitive 3 Changes in cholesterol metabolism and oxidative processes in aging—the beneficial effect of longterm dietary restriction on ageing was explained as effect on cholesterol metabolism 4 Alzheimer’s disease—the connection between neurodegenerative processes associated to the Alzheimer’s disease and the function of the Na–KATPase which is known to be altered by ageing has been experimentally shown Conclusion The recent work of Serbian investigators suggest some new evidence that aging process influences the hormone signaling immunological response cholesterol metabolism and oxidative processes

Keywords: