Genderdependent oxidative variations in liver of

Authors: Seval Aydın Pınar Atukeren Ufuk Çakatay Hafize Uzun Tuncay Altuğ

Publish Date: 2009/11/28

Volume: 11, Issue: 3, Pages: 335-346

PDF Link

Abstract

A shift from redox regulation to oxidative damage is known to contribute organ dysfunction and agingrelated disorders Exposure to reactive oxygen species throughout the lifespan increases the incidence of several liver diseases A redox basis of the loss of antioxidant capacity of aged livers has not been fully elucidated in both genders In the current study we investigated the genderdependent relations between protein carbonyl PCO a commonly used marker of protein oxidation and other protein oxidation parameters such as advanced oxidation protein products AOPP and total thiol TSH Our study also covered other oxidative stress markers such as malondialdehyde MDA lipid hydroperoxides LHP and glutathione GSH in liver tissue of the male and female aged rats PCO and AOPP levels in old male and female rats were significantly higher than those in the young control groups P  0001 and P  001 respectively for male rats P  0001 for both parameters in female rats On the other hand TSH levels were not found to be different between young and old rat groups Plasma MDA levels of old male and female rats were significantly higher compared to those of the young control groups P  001 and P  0001 respectively LHP levels were only found out to be significantly higher in old female rats when compared to those in young male rats GSH levels in old male and female rats were significantly lower than in the corresponding young control groups P  001 for male rats P  005 for female rats Our results demonstrated greater susceptibility to hepatic oxidative damage in females than in males This appears to contradict the general assumption that females are less susceptible to oxidative injury than males areThis work was supported in part by funding from a grant from the Research Fund of The University of Istanbul UDP4/2010 The corresponding author is grateful to linguistic expert Mr Burak Alkan for reading the manuscript and for improvements in the linguistic style

Keywords: