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Title of Journal: Pituitary

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Abbravation: Pituitary

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Springer US

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DOI

10.1002/352760622x.ch49

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1573-7403

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Pituitary gland and βcatenin signaling from onto

Authors: Maria Gueorguiev Ashley B Grossman
Publish Date: 2008/10/23
Volume: 12, Issue: 3, Pages: 245-255
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Abstract

Although pituitary tumors are mostly benign they share certain molecular events with more malignant neoplasia although their precise pathogenesis is far from established The acquisition of new functional characteristics during their evolution suggests a multistep process that leads to tumor transformation Mutations in classical tumor suppressor genes or oncogenes are infrequently associated with pituitary tumorigenesis However alterations in different signaling pathways especially those involved in pituitary gland development have emerged as significant features in pituitary adenomas In particular changes in inhibitory components of the βcatenin pathway and its relationship to the cadherin family of peptides may well play an important role in tumorigenesis We review and assess the role of the βcatenin signaling pathway in the pathogenesis of pituitary adenomas

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  2. Erratum to: An endoscopic modification of the simultaneous ‘above and below’ approach to large pituitary adenomas
  3. Somatostatin receptor ligands in the treatment of acromegaly
  4. Incidence of Cushing’s syndrome and Cushing’s disease in commercially-insured patients <65 years old in the United States
  5. Primary hypothyroidism presenting as pseudoacromegaly
  6. Sellar meningiomas: an endocrinologic perspective
  7. Low frequency of cardniac arrhythmias and lack of structural heart disease in medically-naïve acromegaly patients: a prospective study at baseline and after 1 year of somatostatin analogs treatment
  8. Pituitary tumor apoplexy in patients with Cushing’s disease: endocrinologic and visual outcomes after transsphenoidal surgery
  9. A comparison of cabergoline and bromocriptine on the risk of valvular heart disease in patients with prolactinomas
  10. Sellar and clival plasmacytomas: case series of 5 patients with systematic review of 65 published cases
  11. Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-I criteria for remission
  12. Sellar plasmacytomas: a concise review
  13. Increased clinical symptoms of acromegalic arthropathy in patients with long-term disease control: a prospective follow-up study
  14. Two cases of Kallmann syndrome associated with empty sella
  15. Multiple head and neck tumors following treatment for craniopharyngioma
  16. Modulation of VEGF/Flk-1 receptor expression in the rat pituitary GH3 cell line by growth factors
  17. Acromegalic gigantism, physicians and body snatching. Past or present?
  18. Effectiveness of self- or partner-administration of an extended-release aqueous-gel formulation of lanreotide in lanreotide-naïve patients with acromegaly
  19. Adipsic diabetes insipidus in adult patients
  20. Differential diagnosis of ACTH-dependent hypercortisolism: imaging versus laboratory
  21. A novel variation in the AVP gene resulting in familial neurohypophyseal diabetes insipidus in a large Italian kindred
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