Authors: Jane Lee Edwin Kulubya Barry D Pressman Adam Mamelak Serguei Bannykh Gabriel Zada Odelia Cooper
Publish Date: 2017/03/01
Volume: 20, Issue: 3, Pages: 381-392
Abstract
Five primary case patients include four men and one woman ages 60–77 followed up to 3 years A systematic review identified 65 additional patients of whom 65 presented with cranial nerve palsies and 15 with hypopituitarism Sixteen percent had history of known multiple myeloma MM while 37 were diagnosed concurrently with MM on presentation of parasellar plasmacytoma Imaging showed median tumor size of 38 mm range 4–70 mm with MRI intensity similar to that of other sellar masses Surgical biopsy with immunohistochemical studies confirmed plasmacytoma diagnosis Eightyone percent underwent parasellar radiotherapy and chemotherapy initiated in 59 of the 69 patients with MM Overall survival rate was 74 at followup median 12 months with 18 having parasellar recurrences and 38 progressing to systemic MM after presentation of a solitary plasmacytoma median 3 monthsParasellar plasmacytomas are rare tumors that should be considered in the differential diagnosis for lesions involving the sella and arising from the clivus especially when cranial nerve paresis is apparent even in the absence of known MM Although recurrence rates for parasellar plasmacytoma is low patients should be monitored for progression to MM Treatment depends on the presence of systemic disease at diagnosisAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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