Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Vet Res Commun

Search In Journal Title:

Abbravation: Veterinary Research Communications

Search In Journal Abbravation:

Publisher

Springer Netherlands

Search In Publisher:

DOI

10.1002/poc.3586

Search In DOI:

ISSN

1573-7446

Search In ISSN:
Search In Title Of Papers:

Pharmacokinetic behaviour of enrofloxacin and its

Authors: J J de Lucas M I San Andrés F González R Froyman C Rodríguez
Publish Date: 2008/02/05
Volume: 32, Issue: 4, Pages: 275-279
PDF Link

Abstract

This study compared pharmacokinetic profiles in cattle dosed subcutaneously with two different formulations of enrofloxacin 5 and 10 at a dose of 5 mg/kg Plasma concentrations of enrofloxacin and its active metabolite ciprofloxacin were determined by a HPLC/uv method The pharmacokinetic parameters of enrofloxacin and its metabolite were similar in both injectable formulations Enrofloxacin peak plasma concentration 5 073 ± 032 10 060 ± 014 μg/mL was reached at 121 ± 052 and 138 ± 052 h to 5 and 10 respectively The terminal halflive and area under curve were 234 ± 046 and 259 ± 046 h and 309 ± 081 and 293 ± 058 μg·h/mL to 5 and 10 respectively The AUC/MIC90 and Cmax/MIC90 ratios for both formulations exceed the proposed threshold values for optimized efficacy and minimized resistance development whilst treating infections or septicaemia caused by P multocida and E coliThe authors thank Mr Mariano DíazFlores for his technical assistance Thanks to the staff of the Biblioteca de la Facultad de Veterinaria BUCM for their invaluable help This study was supported by a grant from the Bayer Health Care AG 348/2001 Art 83 LRU/UCM Special thanks to Mr Enrique Rierola from Química Farmacéutica Bayer SA Barcelona Spain and Ms Isabel Uriarte Inchausti DVM

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. A fatal suppurative pneumonia in piglets caused by a pathogenic coagulase-positive strain of Staphylococcus hyicus
  2. Cyclical changes in collagen concentration in relation to growth and development of buffalo corpus luteum
  3. Relationships among functional markers, management, and husbandry in sheep: a Mediterranean case study
  4. Dexmedetomidine chemical restraint of two raptor species undergoing inhalation anaesthesia
  5. Intravenous Infusion of Nitric Oxide in Experimental Pulmonary Hypertension: Biotransformation and Haemodynamics
  6. ISG15 expression in response to double-stranded RNA or LPS in cultured Fetal Bovine Lung (FBL) cells
  7. Identification of some main Streptococcus iniae associated proteins: relationship
  8. Circulating oxidative stress status in dromedary camels infested with sarcoptic mange
  9. Detection of the Maedi Visna Virus in the popliteal lymph nodes of sheep infected by the respiratory route
  10. Three-dimensional microvascolature remodeling study of pig periovulatory follicles using vascular corrosion casts
  11. Effects of the full cream milk somatic cell content on the characteristics of vat milk in the manufacture of Parmigiano-Reggiano cheese
  12. Effects of the full cream milk somatic cell content on the characteristics of vat milk in the manufacture of Parmigiano-Reggiano cheese
  13. Pulmonary kinetic expression of the endothelin system in a swine model of endotoxic shock
  14. Corneal crystalline stromal dystrophy and lipidic metabolism in the dog
  15. Sapogenin Levels in Narthecium ossifragum Plants and Ovis aries Lamb Faeces during Two Alveld Outbreaks in Møre og Romsdal, Norway, 2001
  16. Acute-phase Response Alters the Disposition Kinetics of Cefepime following Intravenous Administration to Rabbits
Search Result: