Circulating oxidative stress status in dromedary c

Authors: Mostafa A Saleh Osman M Mahran M Bassam AlSalahy

Publish Date: 2010/11/18

Volume: 35, Issue: 1, Pages: 35-45

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Abstract

Oxidative stress is an imbalance between radicalgenerating and radicalscavenging activity resulting in oxidation products and tissue damage This study was aimed to evaluate the status of oxidative stress indices in blood of camels naturally infested with S scabiei Fortyseven male camels Camelus dromedaries were divided according to the extent of the infested area with Sarcoptes scabiei into four groups mild MID n = 12 moderate MOD n = 10 severely infested SEV n = 10 and healthy control group n = 15 Blood was used for determination of red cell count RBC hemoglobin Hb packed cell volume PCV serum nitric oxide NO• a free radical ascorbate and albumin concentrations and erythrocytic values of malondialdehyde MDA a marker of lipid peroxidation protein carbonyls PC an indicator of protein oxidation glutathione GSH superoxide dismutase SOD and catalase CAT Decreased levels P  005 of RBC Hb PCV albumin and ascorbate were noticed in MOD and SEV compared to controls with the lowest values P  005 in SEV except for ascorbate where MOD did not differ from SEV Compared to controls NO• gradually increased P  005 in MID followed by MOD and SEV whereas MDA and PC were higher P  005 in MOD and SEV PC was higher P  005 in MOD than SEV In addition the antioxidants GSH SOD and CAT were higher P  005 in MID and lower P  005 in MOD and SEV compared to controls GSH was lower P  005 in SEV compared to MOD Besides Hb was negatively correlated with NO• r = −068 P  0001 MDA r = −053 P  0001 and PC r = −073 P  0001 In conclusion dromedary sarcoptosis is accompanied by a state of oxidative stress process which increased by increasing the area of infestation and may contribute to the pathogenesis of the disease

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