Identification of some main Emphasis Type="Italic

Authors: Fatima El Aamri José Ángel Guillén Daniel Padilla Félix Acosta Fernando Real

Publish Date: 2017/01/14

Volume: 41, Issue: 2, Pages: 85-95

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Abstract

The surfaceassociated proteins play a key role in bacterial physiology and pathogenesis and are the major targets in the development of new vaccines These proteins contribute to the adaptation of bacteria to different hosts and environments To study differences at the genomic level we first sequenced the whole genome of Streptococcus iniae from fish IUSA1 strain and compared it to Streptococcus iniae from human 9117 strain revealing a high similitude between both strains To gain further insights into host and environmentspecific differences we then studied proteins in silico and by High Performance Liquid Chromatography This approach successfully identified 54 secreted and surface proteins including several proteins involved in cell wall synthesis and transport of solutes as well as proteins with yet unknown function These proteins highlight as interesting targets for further investigation in the interaction between Streptococcus iniae and its environment Results reported in this study have shown a first analysis about the predicted and experimental associated proteins of Streptococcus iniae isolated from two different hosts human and fish

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