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Title of Journal: Biometals

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Abbravation: BioMetals

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Springer Netherlands

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DOI

10.1007/978-3-642-23094-3_28

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1572-8773

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The ins and outs of biological zinc sites

Authors: David S Auld
Publish Date: 2009/01/13
Volume: 22, Issue: 1, Pages: 141-148
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Abstract

The inner shell coordination properties of zinc proteins have led to the identification of four types of zinc binding sites catalytic cocatalytic structural and protein interface Outer shell coordination can influence the stability of the zinc site and its function as exemplified herein by the zinc sites in carbonic anhydrase promatrix metalloproteases and alcohol dehydrogenase Agents that disrupt these interactions can lead to increased off rate constants for zinc dpenicillamine is the first drug to inhibit a zinc protease by catalyzing the removal of the metal Since it can accept the released zinc we have referred to it as a catalytic chelator Agents that catalyze the release of the metal in the presence of a scavenger chelator will also inhibit enzyme catalysis and are referred to as enhanced dechelation inhibitors

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  2. In vitro heme and non-heme iron capture from hemoglobin, myoglobin and ferritin by bovine lactoferrin and implications for suppression of reactive oxygen species in vivo
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  5. Investigation of metal sorption behavior of Slp1 from Lysinibacillus sphaericus JG-B53: a combined study using QCM-D, ICP-MS and AFM
  6. Magnetic susceptibility and isothermal remanent magnetization in human tissues: a study case
  7. Heavy metal resistance in Cupriavidus metallidurans CH34 is governed by an intricate transcriptional network
  8. Fluorescence detection of intracellular cadmium with Leadmium Green
  9. Mercury toxicity, molecular response and tolerance in higher plants
  10. Metal concentrations in hair of patients with various head and neck cancers as a diagnostic aid
  11. Effect of oxygen free radicals and nitric oxide on apoptosis of immune organ induced by selenium deficiency in chickens
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  13. Ag nanoparticles generated using bio-reduction and -coating cause microbial killing without cell lysis
  14. XAS analysis of a nanostructured iron polysaccharide produced anaerobically by a strain of Klebsiella oxytoca
  15. Nitrate reduction associated with respiration in Sinorhizobium meliloti 2011 is performed by a membrane-bound molybdoenzyme
  16. Investigation of ascorbate-mediated iron release from ferric phytosiderophores in the presence of nicotianamine
  17. After oxidation, zinc nanoparticles lose their ability to enhance responses to odorants
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  19. Shotgun metabolomic approach based on mass spectrometry for hepatic mitochondria of mice under arsenic exposure
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