Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Biometals

Search In Journal Title:

Abbravation: BioMetals

Search In Journal Abbravation:

Publisher

Springer Netherlands

Search In Publisher:

DOI

10.1016/0022-1902(70)80231-7

Search In DOI:

ISSN

1572-8773

Search In ISSN:
Search In Title Of Papers:

Effect of oxygen free radicals and nitric oxide on

Authors: Ziwei Zhang Jiuli Zhang Yuhong Zhang Qiaohong Wang Shu Li Xiaolong Wang Shiwen Xu
Publish Date: 2013/02/26
Volume: 26, Issue: 2, Pages: 355-365
PDF Link

Abstract

Selenium is an essential element with antioxidant roles in immune regulation but there is little understanding of how Se acts in apoptosis in the immune organs of birds The aim of study was to evaluate the influence of Se deficiency on oxygen free radicals NO and apoptosis in immune organ of chickens 160 1dayold chickens were randomly assigned to two groups of 80 each and were fed on a lowSe diet 0032 mg/kg Se or a control diet 0282 mg/kg Se respectively OFR production in blood was determined on days 30 45 60 and 75 respectively The iNOS–NO system activity in immune organ thymus spleen bursa of fabricius was identified by NO content and NOS activity assay on days 30 45 60 and 75 respectively Apoptosis was measured by DNA ladder analysis ultrastructural observations TdTmediated dUTP nick end labeling TUNEL assay and flow cytometric analysis of apoptotic DNA The transcription of factorassociated suicide caspase3 mRNA was tested by fluorescence quantitative PCR The results showed that OFR production NO and inducible NO synthases iNOS activity in the lowSe group were significantly increased p  005 than in the control group In addition apoptosis was observed in chicken immune organ in the lowSe group The degree and the number of apoptotic cells rose in a timedependent manner The expression of Fas and caspase3 mRNA increased p  005 than in the control group It indicated that the oxidative stress and NO played a causative role in the apoptosis of immune tissues induced by selenium deficiencyThis study was supported by the National Natural Science Foundation of China 30871902 the Science Foundation of the Education Department of Heilongjiang Province 11551030 The authors thank the members of the veterinary internal medicine laboratory in college of veterinary medicine northeast agricultural university for help in feeding the chicks and analyzing the data

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Asthma as a disruption in iron homeostasis
  2. In vitro heme and non-heme iron capture from hemoglobin, myoglobin and ferritin by bovine lactoferrin and implications for suppression of reactive oxygen species in vivo
  3. A role for ferritin in the antioxidant system in coffee cell cultures
  4. Inactivation of bacterial and viral biothreat agents on metallic copper surfaces
  5. Investigation of metal sorption behavior of Slp1 from Lysinibacillus sphaericus JG-B53: a combined study using QCM-D, ICP-MS and AFM
  6. Magnetic susceptibility and isothermal remanent magnetization in human tissues: a study case
  7. Heavy metal resistance in Cupriavidus metallidurans CH34 is governed by an intricate transcriptional network
  8. Fluorescence detection of intracellular cadmium with Leadmium Green
  9. Mercury toxicity, molecular response and tolerance in higher plants
  10. Metal concentrations in hair of patients with various head and neck cancers as a diagnostic aid
  11. Bone and faecal minerals and scanning electron microscopic assessments of femur in rats fed phytic acid extract from sweet potato ( Ipomoea batatas )
  12. Ag nanoparticles generated using bio-reduction and -coating cause microbial killing without cell lysis
  13. XAS analysis of a nanostructured iron polysaccharide produced anaerobically by a strain of Klebsiella oxytoca
  14. Nitrate reduction associated with respiration in Sinorhizobium meliloti 2011 is performed by a membrane-bound molybdoenzyme
  15. Investigation of ascorbate-mediated iron release from ferric phytosiderophores in the presence of nicotianamine
  16. The ins and outs of biological zinc sites
  17. After oxidation, zinc nanoparticles lose their ability to enhance responses to odorants
  18. Analytical studies on the incorporation of aluminium in the cell walls of the marine diatom Stephanopyxis turris
  19. Shotgun metabolomic approach based on mass spectrometry for hepatic mitochondria of mice under arsenic exposure
  20. Arsenic trioxide versus tetraarsenic oxide in biomedical research: misunderstandings and misinterpretations
Search Result: