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Title of Journal: Biometals

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Abbravation: BioMetals

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Springer Netherlands

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DOI

10.1016/j.actamat.2006.10.044

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1572-8773

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In vitro heme and nonheme iron capture from hemog

Authors: Hemalatha Jegasothy Rangika Weerakkody Sophie SelbyPham Louise E Bennett
Publish Date: 2014/10/04
Volume: 27, Issue: 6, Pages: 1371-1382
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Abstract

Lactoferrin Lf present in colostrum and milk is a member of the transferrin family of ironbinding glycoproteins with stronger binding capacity to ferric iron than hemoglobin myoglobin or transferrin Unlike hemoglobin and myoglobin ironbound Lf is reasonably stable to gastric and duodenal digestive conditions Unlike ferrous iron ferric iron is not directly reactive with oxygen supporting the capacity of Lf capture of heme iron to suppress reactive oxygen species ROS production We therefore hypothesized that bovine Lf could capture and thereby terminate the cycle of ROS production by heme iron The transfer of heme iron from either intact or digested forms of hemoglobin and myoglobin and from intact ferritin was demonstrated by in vitro methods monitoring Fesaturation status of Lf by changes in absorptivity at 465 nm The results are discussed in the context of new proposed opportunities for orally administered Lf to regulate oxidative damage associated with heme iron In addition to potentially suppressing oxidative heme–ironmediated tissue damage in the lumen Lf is expected to also reverse the overload of ferritinbound iron that accompanies chronic inflammation and aging These new proposed uses of Lf are additional to known host defense functions that include antimicrobial antiviral properties immune and cancer cell growth regulation The findings and interpretations presented require clinical substantiation and may support important additional protective and therapeutic uses for Lf in the future


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  1. Asthma as a disruption in iron homeostasis
  2. A role for ferritin in the antioxidant system in coffee cell cultures
  3. Inactivation of bacterial and viral biothreat agents on metallic copper surfaces
  4. Investigation of metal sorption behavior of Slp1 from Lysinibacillus sphaericus JG-B53: a combined study using QCM-D, ICP-MS and AFM
  5. Magnetic susceptibility and isothermal remanent magnetization in human tissues: a study case
  6. Heavy metal resistance in Cupriavidus metallidurans CH34 is governed by an intricate transcriptional network
  7. Fluorescence detection of intracellular cadmium with Leadmium Green
  8. Mercury toxicity, molecular response and tolerance in higher plants
  9. Metal concentrations in hair of patients with various head and neck cancers as a diagnostic aid
  10. Effect of oxygen free radicals and nitric oxide on apoptosis of immune organ induced by selenium deficiency in chickens
  11. Bone and faecal minerals and scanning electron microscopic assessments of femur in rats fed phytic acid extract from sweet potato ( Ipomoea batatas )
  12. Ag nanoparticles generated using bio-reduction and -coating cause microbial killing without cell lysis
  13. XAS analysis of a nanostructured iron polysaccharide produced anaerobically by a strain of Klebsiella oxytoca
  14. Nitrate reduction associated with respiration in Sinorhizobium meliloti 2011 is performed by a membrane-bound molybdoenzyme
  15. Investigation of ascorbate-mediated iron release from ferric phytosiderophores in the presence of nicotianamine
  16. The ins and outs of biological zinc sites
  17. After oxidation, zinc nanoparticles lose their ability to enhance responses to odorants
  18. Analytical studies on the incorporation of aluminium in the cell walls of the marine diatom Stephanopyxis turris
  19. Shotgun metabolomic approach based on mass spectrometry for hepatic mitochondria of mice under arsenic exposure
  20. Arsenic trioxide versus tetraarsenic oxide in biomedical research: misunderstandings and misinterpretations

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