Authors: E A Fedorenko D E Duzhii S M Marchenko
Publish Date: 2009/02/04
Volume: 40, Issue: 4, Pages: 238-242
Abstract
As is known an increase in the concentration of Са2+ in the nuclei of nerve cells leads to activation of genes responsible for the formation of longlasting postsynaptic changes mechanisms of memory and learning are based on such changes The pathways necessary for the entry of calcium into the nuclei of hippocampal pyramidal neurons remained unstudied Using a patchclamp technique we studied what types of calcium channels exist in the membranes of isolated nuclei of pyramidal neurons of the hippocampal СА1 area In the inner nuclear membrane of these cells we for the first time found inositol trisphosphate receptors IP3Rs activated by inositol trisphosphate applied in the concentration of ≥01 μM The conductivity of single channels of such receptors was on average 366 pS these channels were permeable for both monovalent and bivalent cations Our data indicate that the nuclear envelope of pyramidal neurons of the hippocampal СА1 area can play the role of the calcium store from which Са2+ enter the cell nucleus directly
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