Authors: M I Kosar T Demir A Demirkazik K Deveci E Ozdemir S Gulturk
Publish Date: 2012/04/05
Volume: 44, Issue: 1, Pages: 56-62
Abstract
The effects of repeated applications of alternating sinusoidal 50 Hz magnetic field MF B = 50 mT 165minlong sessions everyday each including four 30minlong exposures separated by 15minlong intervals carried out for 30 days on thermonociception estimated using the tailflick test were examined in intact rats diabetic rats induction by streptozotocin and diabetic rats treated with insulin Exposures to MF led to mild several percent increases in the tailflick latency TFL immediately after each session and a sustained rather significant rise in this parameter increment up to 40 developing with some delay from 2 to 4 days The latter effect was limited in time lasting 2 days long then the TFLs tended to rapidly return to initial or nearly initial values This intense hypoalgesic effect induced by MF exposures was observed on days 3 and 4 in normal rats on days 4 and 5 in diabetic rats and on days 5 and 6 in diabetic rats treated with insulin Significant increases in the mean arterial blood pressure were observed in diabetic rats exposures to MF exerted no significant influence on this parameter in both normal and diabetic animals Mechanisms of the development of diabetic neuropathy and those of the hypoalgesic actions of MF are discussed The MFinduced antinociception seems to be in future an attractive choice for the relief of acute and chronic symptoms in diabetic neuropathy but further detailed studies are necessary to find optimum MF parameters modes of application and “time windows”
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