Authors: M G Matvienko A S Pustovalov N A Buzynskaya N E Dzerzhinsky
Publish Date: 2013/12/18
Volume: 45, Issue: 5-6, Pages: 417-422
Abstract
In experiments on prepubescent onemonthold male albino rats we studied the effects of pharmacological blockade and activation of kisspeptinergic and αadrenergic systems on neurocytes and astrocytes of the preoptic hypothalamic nucleus Intracerebroventricular injection of kisspeptin induced activation of the processes of synthesis of proteins in neurons and astrocytes of this nucleus which was manifested in significantly greater mean values of crosssection areas of the nuclei of these cell units Injections of a blocker of kisspeptin receptors Р234 inhibited synthetic activity in neurons but not in astrocytes Mezaton intensely activated the abovementioned activity in cells of both types such activation could not be eliminated completely by simultaneous injection of the kisspeptin antagonist Р234 Prazosin suppressed synthetic processes in neurons but not in astrocytes In the case of combined introduction of prazosin and kisspeptin the effect of inhibition of protein synthesis in neurons was significantly weakened but could not be eliminated completely in astrocytes the functional activity increased We discuss the mechanisms of action of the αadrenergic and kisspeptinergic systems on production of gonadotropinreleasing hormone gonadoliberin by cells of the preoptic hypothalamic nucleus and the actions of these events on the functioning of the reproductive system
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