Authors: S Babri M Amani G Mohaddes A Alihemmati H Ebrahimi
Publish Date: 2012/10/31
Volume: 44, Issue: 5, Pages: 387-393
Abstract
In our study we examined the protective effect of troxerutin a natural bioflavonoid on βamyloid Aβ 142induced impairments of learning and memory Male Wistar rats 300350 g were divided into six groups sham Aβ 142 Aβ 421injected and three groups Aβ 142injected plus treatment with three different doses of troxerutin 50 150 and 300 mg/kg for 8 consecutive days The Aβ peptides were injected intracerebroventricularly icv into the right lateral ventricle 8 days later the Morris water maze test was performed to assess spatial learning and memory Our results showed that troxerutin at lower doses 50 and 150 mg/kg exerted no significant effect on Aβinduced impairment of memory performance but the dose of 300 mg/kg significantly protected against the above impairment of spatial learning and memory in Aβ 142treated animals The beneficial effects of troxerutin may partly be due to its antioxidant and antiinflammatory activities and to modifications in the cholinergic system
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