Authors: Siddhartha G Kapnadak Ivan Mikolaenko Kyle Enfield Daryl R Gress Barnett R Nathan
Publish Date: 2010/01/12
Volume: 12, Issue: 3, Pages: 395-399
Abstract
Central hypoventilation syndrome “Ondine’s Curse” is an infrequent disorder that can lead to serious acute or chronic health consequences This syndrome especially in adults is rare and even less frequent in the absence of clear pathogenic lesions on MRI In addition we are not aware of any previously reported cases with associated cranial nerve neuralgiasWe describe a patient with baseline trigeminal and glossopharyngeal neuralgia admitted with episodes of severe hypoventilatory failure of central origin consistent with “Ondine’s Curse” After evaluation she was found to have a medullary capillary telangiectasia thought to be the causative lesion and which could explain her complete neurologic and hypoventilatory syndrome The patient was treated with placement of a diaphragmatic pacing system which has been effective thus farThis case illustrates the need for investigation of centrally mediated apnea especially when cooccurring cranial nerve neuralgia is present and cardiopulmonary evaluation is negative It provides an example of capillary telangiectasia as the causative lesion one that to our knowledge has not been reported before
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