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Title of Journal: Neurocrit Care

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Abbravation: Neurocritical Care

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Humana Press Inc

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ISSN

1556-0961

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Levetiracetam is Associated with Improved Cognitiv

Authors: Scott Taylor Robin J Heinrichs Jeff M Janzen As’ad Ehtisham
Publish Date: 2010/10/02
Volume: 15, Issue: 1, Pages: 80-84
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Abstract

To date common therapy in patients with intracranial hemorrhage ICH includes prophylaxis of seizure using antiepileptic drugs commonly phenytoin Phenytoin therapy is associated with a high incidence of cognitive disturbance Levetiracetam is known to cause less cognitive disruption and may be a suitable alternative for seizure prophylaxis Cognitive outcomes in ICH patients receiving seizure prophylaxis with levetiracetam or phenytoin are comparedStatistically significant results included higher Glasgow Coma Scores GCS at dismissal median 14 vs 11 P = 0023 lower seizure incidence 00 vs 8 P = 003 for patients receiving levetiracetam than those treated with phenytoin and patients being discharged home 217 vs 16 P = 003 Observed trends included greater cognitive function retention rate 567 vs 36 P = 008Despite similarities in hemorrhage type and severity at onset patients receiving levetiracetam had better cognition at discharge and fewer seizures than patients receiving phenytoin These data suggest that levetiracetam is more effective than phenytoin for seizure prophylaxis without suppression of cognitive abilities in patients with ICH

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Other Papers In This Journal:
  1. Ondine’s Curse with Accompanying Trigeminal and Glossopharyngeal Neuralgia Secondary to Medullary Telangiectasia
  2. Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage
  3. Critical Care Guidelines on the Endovascular Management of Cerebral Vasospasm
  4. Prompt Recognition and Management of Postoperative Intracranial Hypotension-Associated Venous Congestion: A Case Report
  5. The Effect of Decompressive Hemicraniectomy on Brain Temperature After Severe Brain Injury
  6. High Dose Deferoxamine in Intracerebral Hemorrhage (H i -D ef ) Trial: Rationale, Design, and Methods
  7. Therapeutic Temperature Modulation for Fever After Intracerebral Hemorrhage
  8. Aggressive Care After a Massive Stroke in Young Patients: Is That What They Want?
  9. Research and Technology in Neurocritical Care
  10. Modeling the Pattern of Contrast Extravasation in Acute Intracerebral Hemorrhage Using Dynamic Contrast-Enhanced MR
  11. Biomarkers Improve Clinical Outcome Predictors of Mortality Following Non-Penetrating Severe Traumatic Brain Injury
  12. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage
  13. Long-Term Outcome Call into Question the Benefit of Positive Fluid Balance and Colloid Treatment After Aneurysmal Subarachnoid Hemorrhage
  14. 1 H-MR Spectroscopy in Traumatic Brain Injury
  15. Emergency Neurological Life Support: Status Epilepticus
  16. Ventilation Practices in Subarachnoid Hemorrhage: A Cohort Study Exploring the Use of Lung Protective Ventilation
  17. Systemic Administration of LPS Worsens Delayed Deterioration Associated with Vasospasm After Subarachnoid Hemorrhage Through a Myeloid Cell-Dependent Mechanism
  18. Treatment of Elevated Intracranial Pressure with Hyperosmolar Therapy in Patients with Renal Failure
  19. Therapeutic Hypothermia for Adult Viral Meningoencephalitis
  20. Effects of Red Blood Cell Transfusion on Long-Term Disability of Patients with Traumatic Brain Injury
  21. Emergency Neurological Life Support: Approach to the Patient with Coma
  22. Macroglossia Associated with Brainstem Injury
  23. Head Computed Tomography Scanning During Pediatric Neurocritical Care: Diagnostic Yield and the Utility of Portable Studies
  24. Monitoring of Hematological and Hemostatic Parameters in Neurocritical Care Patients
  25. The Effect of Increased Inspired Fraction of Oxygen on Brain Tissue Oxygen Tension in Children with Severe Traumatic Brain Injury
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