Authors: Anthony A Figaji Eugene Zwane A Graham Fieggen Andrew C Argent Peter D Le Roux Jonathan C Peter
Publish Date: 2010/03/16
Volume: 12, Issue: 3, Pages: 430-437
Abstract
A prospective observational study of patients who underwent PbO2 monitoring and an oxygen challenge test temporary increase of FiO2 for 15 min was undertaken Pre and posttest values for arterial partial pressure of oxygen PaO2 PbO2 and arterial oxygen content CaO2 were examined while controlling for any changes in arterial carbon dioxide tension and cerebral perfusion pressure during the test Baseline transcranial Doppler studies were done Outcome was assessed at 6 monthsA total of 43 tests were performed in 28 patients In 35 tests in 24 patients the PbO2 monitor was in normalappearing white matter and in eight tests in four patients the monitor was in a pericontusional location When catheters were pericontusional or in normal white matter the baseline PbO2/PaO2 ratio was similar PaO2 P 00001 and PbO2 P 00001 significantly increased when FiO2 was increased The magnitude of the PbO2 response ∆PbO2 was correlated with ∆PaO2 P 00001 R 2 = 037 and ∆CaO2 P = 0001 R 2 = 023 The ∆PbO2/∆PaO2 ratio oxygen reactivity varied between patients was related to the baseline PbO2 P = 0001 r = 054 and was inversely related to outcome P = 002 confidence interval 003–078
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