Authors: Aaron S Lord Sarah Karinja Hector Lantigua Amanda Carpenter J Michael Schmidt Jan Claassen Sachin Agarwal E Sander Connolly Stephan A Mayer Neeraj Badjatia
Publish Date: 2014/01/14
Volume: 21, Issue: 2, Pages: 200-206
Abstract
We performed a retrospective case–control study of patients admitted with spontaneous ICH having two consecutive fevers ≥383 °C despite acetaminophen administration Cases were enrolled from a prospective database of patients receiving TTM from 2006 to 2010 All cases received TTM for fever control with goal temperature of 37 °C with a shivercontrol protocol Controls were matched in severity by ICH score and retrospectively obtained from 2001 to 2004 before routine use of TTM for ICH Primary outcome was dischargemodified Rankin scoreForty patients were enrolled in each group Median admission ICH Score ICH volume and GCS were similar TTM was initiated with a median of 3 days after ICH onset and for a median duration of 7 days Mean daily T max was significantly higher in the control group over the first 12 days 381 vs 387 °C p ≤ 0001 The TTM group had more days of IV sedation median 8 vs 1 p 0001 and mechanical ventilation 18 vs 9 p = 0003 and more frequently underwent tracheostomy 55 vs 23 p = 0005 Mean NICU length of stay was longer for TTM patients 15 vs 11 days p = 0007 There was no difference in discharge outcomes between the two groups overall mortality 33 moderate or severe disability 67 Stephan Mayer has received consulting fees from Acetlion Biogen Idec CSL Behring Haemonetics Medivance/CR Bard Neuroptics Orsan Technologies Pfizer Sage Therapeutics SanofiAventis Stryker and Edge Therapeutics Stock/Stock Options in Orsan Technologies
Keywords: