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Title of Journal: Neurocrit Care

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Abbravation: Neurocritical Care

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Springer US

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DOI

10.1007/978-1-4614-8544-5

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ISSN

1556-0961

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Biomarkers Improve Clinical Outcome Predictors of

Authors: Linda Papa Claudia S Robertson Kevin K W Wang Gretchen M Brophy H Julia Hannay Shelley Heaton Ilona Schmalfuss Andrea Gabrielli Ronald L Hayes Steven A Robicsek
Publish Date: 2014/07/23
Volume: 22, Issue: 1, Pages: 52-64
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Abstract

This prospective study conducted at two Level 1 Trauma Centers enrolled adults with severe TBI GCS ≤8 requiring a ventriculostomy as well as control subjects Ventricular CSF was sampled within 24h of injury and analyzed for seven candidate biomarkers UCHL1 MAP2 SBDP150 SBDP145 SBDP120 MBP and S100B The International Mission on Prognosis and Analysis of Clinical Trials in TBI IMPACT scores Core Extended and Lab were calculated for each patient to determine risk of 6months mortality The IMPACT models and biomarkers were assessed alone and in combinationThere were 152 patients enrolled 131 TBI patients and 21 control patients Thirty six 27  patients did not survive to 6 months Biomarkers were all significantly elevated in TBI versus controls p  0001 Peak levels of UCHL1 SBDP145 MAP2 and MBP were significantly higher in nonsurvivors p  005 Of the seven biomarkers measured at 12h postinjury MAP2 p = 0004 UCHL1 p = 0024 and MBP p = 0037 had significant unadjusted hazard ratios Of the seven biomarkers measured at the earliest time within 24h MAP2 p = 0002 UCHL1 p = 0016 MBP p = 0021 and SBDP145 0029 had the most significant elevations When the IMPACT Extended Model was combined with the biomarkers MAP2 contributed most significantly to the survival models with sensitivities of 97–100 This study was funded by NIH RO1 NS052831 “Biochemical Markers of Severe Traumatic Brain Injury” Drs Brophy and Papa are consultants of Banyan Biomarkers Inc but receive no stocks or royalties from the company and will not benefit financially from this publication Dr Hayes and Wang own stock receive royalties from Banyan Biomarkers Inc and as such may benefit financially as a result of the outcomes of this research or work reported in this publication

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  1. Ondine’s Curse with Accompanying Trigeminal and Glossopharyngeal Neuralgia Secondary to Medullary Telangiectasia
  2. Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage
  3. Critical Care Guidelines on the Endovascular Management of Cerebral Vasospasm
  4. Prompt Recognition and Management of Postoperative Intracranial Hypotension-Associated Venous Congestion: A Case Report
  5. The Effect of Decompressive Hemicraniectomy on Brain Temperature After Severe Brain Injury
  6. High Dose Deferoxamine in Intracerebral Hemorrhage (H i -D ef ) Trial: Rationale, Design, and Methods
  7. Therapeutic Temperature Modulation for Fever After Intracerebral Hemorrhage
  8. Aggressive Care After a Massive Stroke in Young Patients: Is That What They Want?
  9. Research and Technology in Neurocritical Care
  10. Modeling the Pattern of Contrast Extravasation in Acute Intracerebral Hemorrhage Using Dynamic Contrast-Enhanced MR
  11. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage
  12. Long-Term Outcome Call into Question the Benefit of Positive Fluid Balance and Colloid Treatment After Aneurysmal Subarachnoid Hemorrhage
  13. 1 H-MR Spectroscopy in Traumatic Brain Injury
  14. Emergency Neurological Life Support: Status Epilepticus
  15. Ventilation Practices in Subarachnoid Hemorrhage: A Cohort Study Exploring the Use of Lung Protective Ventilation
  16. Levetiracetam is Associated with Improved Cognitive Outcome for Patients with Intracranial Hemorrhage
  17. Systemic Administration of LPS Worsens Delayed Deterioration Associated with Vasospasm After Subarachnoid Hemorrhage Through a Myeloid Cell-Dependent Mechanism
  18. Treatment of Elevated Intracranial Pressure with Hyperosmolar Therapy in Patients with Renal Failure
  19. Therapeutic Hypothermia for Adult Viral Meningoencephalitis
  20. Effects of Red Blood Cell Transfusion on Long-Term Disability of Patients with Traumatic Brain Injury
  21. Emergency Neurological Life Support: Approach to the Patient with Coma
  22. Macroglossia Associated with Brainstem Injury
  23. Head Computed Tomography Scanning During Pediatric Neurocritical Care: Diagnostic Yield and the Utility of Portable Studies
  24. Monitoring of Hematological and Hemostatic Parameters in Neurocritical Care Patients
  25. The Effect of Increased Inspired Fraction of Oxygen on Brain Tissue Oxygen Tension in Children with Severe Traumatic Brain Injury
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