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Title of Journal: J Microbiol

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Abbravation: The Journal of Microbiology

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The Microbiological Society of Korea

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10.1007/bf01086126

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1976-3794

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AntiHIV1 efficacy of extracts from medicinal pla

Authors: SuA Lee SeongKarp Hong ChangIl Suh MiHwa Oh JeongHo Park ByoungWook Choi SeungWon Park SoonYoung Paik
Publish Date: 2010/05/01
Volume: 48, Issue: 2, Pages: 249-252
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Abstract

The antiHIV1 activities of butanol hexane chloroform and water extracts from four widely used folk medicinal plants Sophora flavescens Tulipa edulis Herba ephedra and Pachyma hoelen Rumph were evaluated in this study The hexane extract of Pachyma hoelen Rumph PH4 showed effective inhibition against HIV1 The 50 effective concentration EC50 of PH4 was 373 μg/ml in the p24 antigen assay and 368 in the HIV1 recombinant RT activity test at 200 μg/ml In addition the PH4 showed the protective effect on the infected MT4 cells with a 582 rate of protection The 50 cytotoxic concentration CC50 of PH4 was 1006 μg/ml These results suggest that PH4 from Pachyma hoelen Rumph might be the candidate for the chemotherapy agent against HIV1 infection with further study


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