Authors: John A Schneider Stuart Michaels Sabitha R Gandham Rachel McFadden Chuanhong Liao Vijay V Yeldandi Ganesh Oruganti
Publish Date: 2011/06/17
Volume: 16, Issue: 2, Pages: 350-359
Abstract
The role of circumcision in the transmission of human immunodeficiency virus HIV among men who have sex with men MSM in resource restricted regions is poorly understood This study explored the association of circumcision with HIV seroprevalence in conjunction with other risk factors such as marriage and sex position for a population of MSM in India Participants n = 387 were recruited from six dropin centers in a large city in southern India The overall HIV prevalence in this sample was high at 186 Bivariate and multivariable analyses revealed a concentration of risk among receptive only married and uncircumcised MSM with HIV prevalence in this group reaching nearly 50 The adjusted odds of HIV infection amongst circumcised men was less than one fifth that of uncircumcised men adjusted odds ratio AOR 017 95 CI 007–046 P 0001 Within the group of receptive only MSM infection was found to be lower among circumcised individuals AOR 030 95 CI 012–076 P 005 in the context of circumcised MSM engaging in more UAI having a more recent same sex encounter and less lubricant use when compared to uncircumcised receptive men To further explain these results future studies should focus on epidemiologic analyses of risk augmented by social and sexual network analyses of MSM mixingThis study was supported in part by the American Foundation for AIDS Research Dr Schneider was supported by the National Center for Research Resources KL2RR025000 National Institutes of Health We would like to acknowledge the study participants for their time and contribution to the study design We would like to thank Mithrudu for their collaboration on this project and Dr Rajender for treating study participants who were in need
Keywords: