Journal Title
Title of Journal: Virol Sin
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Abbravation: Virologica Sinica
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Publisher
SP Wuhan Institute of Virology, CAS
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Authors: Jian Qiu Bo Qin Simon Rayner Chunchen Wu Rongjuan Pei Song Xu Yun Wang Xinwen Chen
Publish Date: 2011/04/07
Volume: 26, Issue: 2, Pages: 131-138
Abstract
Naturally occurring mutations in surface proteins of Hepatitis B virus HBV usually result in altered hepatitis B surface antigen HBsAg secretion efficiency In the present study we reported two conserved residues M75 and M103 with respect to HBsAg mutations of which not only attenuated HBsAg secretion M75 only but also suppressed HBV genome replication without compromising the overlapping pgene product We also found M75 and M103 can initiate truncated surface protein TSPs synthesis upon overexpression of fulllength surface proteins which may possibly contribute to HBV genome replication However attempts to rescue replicationdefective HBV mutant by coexpression of TSPs initiated from M75 or M103 were unsuccessful which indicated surface proteins rather than the putative TSPs were involved in regulation of HBV genome replication
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