Polyomavirus interaction with the DNA damage respo

Authors: Joshua L Justice Brandy Verhalen Mengxi Jiang

Publish Date: 2015/04/20

Volume: 30, Issue: 2, Pages: 122-129

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Abstract

Viruses are obligate intracellular parasites that subvert cellular metabolism and pathways to mediate their own replication—normally at the expense of the host cell Polyomaviruses are a group of small DNA viruses which have long been studied as a model for eukaryotic DNA replication Polyomaviruses manipulate host replication proteins as well as proteins involved in DNA maintenance and repair to serve as essential cofactors for productive infection Moreover evidence suggests that polyomavirus infection poses a unique genotoxic threat to the host cell In response to any source of DNA damage cells must initiate an effective DNA damage response DDR to maintain genomic integrity wherein two protein kinases ataxia telangiectasia mutated ATM and ATM and Rad3related ATR are major regulators of DNA damage recognition and repair Recent investigation suggests that these essential DDR proteins are required for productive polyomavirus infection This review will focus on polyomaviruses and their interaction with ATM and ATRmediated DNA damage responses and the effect of this interaction on host genomic stability

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