Authors: Katia Lofano Mariabeatrice Principi Maria Principia Scavo Maria Pricci Enzo Ierardi Alfredo Di Leo
Publish Date: 2012/08/10
Volume: 44, Issue: 1, Pages: 1-11
Abstract
Interest in the possibility that diet might help to reduce the risk of colorectal cancer dates back to 1970 based on both the large variation in rates of specific cancers in different countries and the impressive changes observed in the incidence of cancer in migrants from low to highrisk areas Here we report the state of art of literature data about this topicThree sections have been separately considered chemoprevention of first tumor onset chemoprevention of recurrence after surgery and chemoprevention of polyp recurrence in the course of the followup of subjects with elevated risk A particular attention has been pointed to dietary factors and survival whose relevance is showing a growing interestLiterature data are convincing for a protective role on the onset of preneoplastic and neoplastic lesions for some foods such as fibers vitamin A and D folic acid calcium antioxidants and promising perspectives for some substances such as phytoestrogens Less evidencebased data are available on the possibility to avoid the recurrence of the disease or to affect its mortality with dietary habits Future perspectives will be directed be not only to identify new dietary style able to prevent the onset of neoplastic lesion of the colon but also to realize an effective chemoprevention
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