Authors: S James Cullom James A Case Staci A Courter A Iain McGhie Timothy M Bateman
Publish Date: 2012/11/28
Volume: 20, Issue: 1, Pages: 76-83
Abstract
Dipyridamole is used for stress 82rubidium chloride 82RbCl PET because of its long hyperemic duration Regadenoson has advantages of a fixed dose and favorable symptom profile but its mean maximal hyperemia is only 23 minutes To determine its suitability for 82RbCl PET we imaged subjects using a regadenoson protocol based on its hyperemic response and compared the images in the same subjects having dipyridamole PETIn 32 subjects 23 M we assessed visually by blinded interpretation and quantitatively compared summed stress and difference scores total perfusion deficit TPD LVEF LV volumes and change in stressrest function Linear correlation and BlandAltman analysis of the paired measurements were applied for evaluation of differences Paired t test and Pearson’s correlation were applied for testing of significanceThe images were interpreted the same by visual assessment Twentysix 26 subjects had reversible defects by quantitation the SSS was 129 ± 70 and 141 ± 64 P = 23 and SDS was 70 ± 68 versus 76 ± 62 P = 40 for dipyridamole and regadenoson respectively Six 6 subjects had 5 likelihood of CAD and were normal by both All paired measurements showed a high positive correlation between regadenoson and dipyridamole stress segmental perfusion Reg = 093Dip + 44 r = 088 TPD Reg = 094Dip + 041 r = 093 LVEF Reg = 092Dip + 47 r = 095 stress minus rest LVEF Reg = 087Dip − 099 r = 082
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