Authors: Murray Matangi Peter Dutchak
Publish Date: 2014/07/01
Volume: 21, Issue: 5, Pages: 1039-1039
Abstract
Caffeine Theophylline and Aminophylline are all Xanthine derivatives acting as nonselective adenosine receptor antagonists thereby inhibiting Adenosine1 Caffeine is structurally similar to Theophylline Caffeine = C8H10N4O2 Theophylline = C7H8N4O2There were 534 males and 420 females mean age of 668 ± 109 years Fiftyfive symptomatic patients with ischemic ECG changes and/or hypotension required Aminophylline 58 One hundred and seven symptomatic patients with ischemic ECG changes and/or hypotension did not require Aminophylline 112 Sixtynine asymptomatic patients with ischemic ECG changes and/or hypotension did not require Aminophylline 72 Using these figures a very selective utilization of Aminophylline could have been a reduced from 242 to 58 Our use of Aminophylline was reduced from routine 100 to 58Buccal Caffeine 40 mg is an alternative method of reversing Persantine Intravenous Aminophylline must be available for those patients who fail to respond Any other Caffeine preparation coffee tea chocolate energy drinks and caffeine tablets would have delayed absorption and therefore less likely to be effective Lexiscan Regadenoson is only available through a “special access” program in Canada Buccal Caffeine should also reverse the adverse effects of LexiscanWe use buccal Caffeine routinely after Persantine MPI and reserve intravenous Aminophylline for the caffeine nonresponders We are currently investigating an 80 mg dose of buccal Caffeine to see if we can further reduce the percentage of nonresponders
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