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Title of Journal: J Nucl Cardiol

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Abbravation: Journal of Nuclear Cardiology

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Springer-Verlag

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DOI

10.1007/bf03058124

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1532-6551

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Acute hyperglycemia causes microvascular damage l

Authors: Katsuhiko Sarazawa Akira Nakano Hiroyasu Uzui Yasuhiko Mitsuke Tohru Geshi Hidehiko Okazawa Takanori Ueda JongDae Lee
Publish Date: 2012/02/08
Volume: 19, Issue: 3, Pages: 507-514
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Abstract

Although acute hyperglycemia AHG is associated with poor outcomes in STsegment elevation myocardial infarction STEMI patients underlying mechanisms have not been fully elucidated We investigated the influence of AHG on myocardial microcirculation in reperfused STEMI patientsThirtyfour STEMI patients were divided into 2 groups according to the presence Group H n = 11 or the absence Group L n = 23 of AHG Myocardial blood flow MBF and myocardial flow reserve MFR in the infarctrelated area were compared between 2 groups using 13Nammonia positron emission tomography Wall motion abnormality scores WMASs and enddiastolic volume indices EDVI were also assessed at 1 and 6 months after the onset Although resting MBF was similar MFR was lower in Group H than in Group L 169 ± 037 vs 239 ± 056 P = 001 WMAS was greater in Group H than in Group L at both 1 month 74 ± 37 vs 37 ± 30 P = 011 and 6 months 73 ± 39 vs 31 ± 34 P = 015 EDVI tended to be greater in Group H than in Group L at 6 months 1038 ± 429 vs 739 ± 160 mL/m2 P = 071 Multivariate analysis showed AHG to be independently associated with low MFRWe are grateful to Mr Katsuya Sugimoto and all other cyclotron staff members for their technical assistance We also wish to thank the technical and nursing staff of our cardiac catheterization laboratory and coronary care unit for their highly skilled assistance

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