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Journal Title

Title of Journal: Cardiovasc Intervent Radiol

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Abbravation: CardioVascular and Interventional Radiology

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Springer-Verlag

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DOI

10.1016/0006-2952(61)90298-2

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ISSN

1432-086X

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Toxicity of Doxorubicin on Pig Liver After Chemoem

Authors: Valentin Verret Julien Namur Saïda Homayra Ghegediban Michel Wassef Laurence Moine Michel Bonneau JeanPierre Pelage Alexandre Laurent
Publish Date: 2012/03/23
Volume: 36, Issue: 1, Pages: 204-212
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Abstract

The left hepatic arteries of two pigs were embolized with 1 mL of doxorubicinloaded 25 mg DoxMS or nonloaded BlandMS microspheres The histopathological effects of the embolization were analyzed at 1 week RNAs extracted from both the embolized and control liver areas were hybridized onto Agilent porcine microarrays Genes showing significantly different expression p  001 foldchange  2 between two groups were classified by biological processAt 1 week after embolization DoxMS caused arterial and parenchymal necrosis in 51 and 38  of embolized vessels respectively By contrast BlandMS did not cause any tissue damage Upregulated genes following embolization with DoxMS vs BlandMS n = 353 were mainly involved in cell death apoptosis and metabolism of doxorubicin Downregulated genes n = 120 were mainly related to hepatic functions including enzymes of lipid and carbohydrate metabolisms Upregulated genes included genes related to cell proliferation growth factors and transcription factors tissue remodeling MMPs and several collagen types inflammatory reaction interleukins and chemokines and angiogenesis angiogenic factors and HIF1a pathway all of which play an important role in liver healing and regenerationDoxMS caused lesions to the liver provoked cell death and disturbed liver metabolism An inflammatory repair process with cell proliferation tissue remodeling and angiogenesis was rapidly initiated during the first week after chemoembolization This pilot study provides a comprehensive method to compare different types of DoxMS in healthy animals or tumor models

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