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Title of Journal: Immunogenetics

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Abbravation: Immunogenetics

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Springer-Verlag

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DOI

10.1007/JHEP02(2015)160

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1432-1211

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Genotype frequency and Emphasis Type="Italic"F/

Authors: Qing Lan Min Shen Dino GarciaRossi Stephen Chanock Tongzhang Zheng Sonja I Berndt Vinita Puri Guilan Li Xingzhou He Robert Welch Shelia H Zahm Luoping Zhang Yawei Zhang Martyn Smith Sophia S Wang Brian CH Chiu Martha Linet Richard Hayes Nathaniel Rothman Meredith Yeager
Publish Date: 2007/10/16
Volume: 59, Issue: 11, Pages: 839-852
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Abstract

Selection and genetic drift can create genetic differences between populations Cytokines and chemokines play an important role in both hematopoietic development and the inflammatory response We compared the genotype frequencies of 45 SNPs in 30 cytokine and chemokine genes in two healthy Chinese populations and one Caucasian population Several SNPs in IL4 had substantial genetic differentiation between the Chinese and Caucasian populations F ST ~040 and displayed a strikingly different haplotype distribution To further characterize common genetic variation in worldwide populations at the IL4 locus we genotyped 9 SNPs at the IL4 gene in the Human Diversity Panel’s N = 1056 individuals from 52 world geographic regions We observed low haplotype diversity yet strikingly different haplotype frequencies between nonAfrican populations which may indicate different selective pressures on the IL4 gene in different parts of the world SNPs in CSF2 IL6 IL10 CTLA4 and CX3CR1 showed moderate genetic differentiation between the Chinese and Caucasian populations 015  F ST  025 These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immunerelated diseases that vary in incidence across these two populations may be warranted

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