Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Immunogenetics

Search In Journal Title:

Abbravation: Immunogenetics

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1002/zaac.201100012

Search In DOI:

ISSN

1432-1211

Search In ISSN:
Search In Title Of Papers:

Is there a role for mannanbinding lectin in the d

Authors: Christina Hoffmann Peter Hoffmann Andreas Lun Carsten Büning Falk Hiepe Hans U Scherer Elisabeth SteinhagenThiessen Andreas Weimann
Publish Date: 2010/02/25
Volume: 62, Issue: 4, Pages: 231-235
PDF Link

Abstract

Mannanbinding lectin MBL activates the lectincomplement pathway as part of the innate immune defence by binding to the surface of microorganisms Therefore MBL2 presents an interesting candidate gene for the inflammatory bowel diseases ulcerative colitis UC and Crohns disease CD In our study we evaluated the MBL serum concentrations and genotypes for diagnostic and classification purposes of patients with CD and UC The MBL serum concentration was analysed in 98 CD patients and in 83 UC patients In total 82 patients with inflammatory rheumatic disorders and 189 healthy individuals served as controls All study subjects were genotyped for the MBL2 polymorphisms G54D G57E and R52C and the NOD2 CARD15 mutations R702W G908R and L1007fsinsC Neither the median MBL serum concentration nor the MBL2 genotype distribution differed significantly between cohorts Measurement of MBL serum concentrations offers no benefit for the diagnosis of CD or UC

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Recent duplication and inter-locus gene conversion in major histocompatibility class II genes in a teleost, the three-spined stickleback
  2. A mutation in KIR3DS1 that results in truncation and lack of cell surface expression
  3. Ly49 genes in non-rodent mammals
  4. Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
  5. HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer
  6. Evolution of MHC class I in the Order Crocodylia
  7. A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01
  8. Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques ( Macaca fascicularis )
  9. Polymorphism and evolution in the constant region of the T-cell receptor beta chain in an advanced teleost fish
  10. Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters
  11. At least one YMHCI molecule in the chicken is alloimmunogenic and dynamically expressed on spleen cells during development
  12. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers
Search Result: