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Title of Journal: Immunogenetics

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Abbravation: Immunogenetics

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Springer-Verlag

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1432-1211

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HLACw group 1 ligands for KIR increase susceptibi

Authors: Maureen P Martin Ingrid B Borecki Zhengyan Zhang Loan Nguyen Duanduan Ma Xiaojiang Gao Ying Qi Mary Carrington Janet S Rader
Publish Date: 2010/09/21
Volume: 62, Issue: 11-12, Pages: 761-765
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Abstract

Inherited genetic polymorphisms within immune response genes have been shown to associate with risk of invasive cervical cancer ICC and its immediate precursor cervical intraepithelial neoplasia grade 3 Here we used the transmission/disequilibrium test to detect diseaseliability alleles and investigate haplotype transmission of KIR and HLA class I polymorphisms in a large familybased population of women with cervical cancer and their biological parents 359 trios The effect of distinct human papillomavirus types was also explored HLACw group 1 HLACw alleles with asparagine at position 80 which serves as ligand for certain killer immunoglobulinlike receptors KIR was significantly overtransmitted in women with ICC P = 004 and particularly in the subgroup of women infected with high risk HPV16 or 18 subtypes P = 0008 These data support the involvement of the HLAC locus in modulating the risk of cervical neoplasia perhaps through its function as ligands for KIR but functional studies are essential to confirm this hypothesisThis work was supported by National Cancer Institute grants 5R01CA094141 and 5R01CA095713 This project has been funded in whole or in part with federal funds from the National Cancer Institute National Institutes of Health under Contract No HHSN261200800001E The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services nor does mention of trade names commercial products or organizations imply endorsement by the US Government This research was supported in part by the Intramural Research Program of the NIH National Cancer Institute Center for Cancer Research

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  12. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers
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