Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Immunogenetics

Search In Journal Title:

Abbravation: Immunogenetics

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1007/s00534-002-0802-y

Search In DOI:

ISSN

1432-1211

Search In ISSN:
Search In Title Of Papers:

Evolution of MHC class I in the Order Crocodylia

Authors: Weerachai Jaratlerdsiri Sally R Isberg Damien P Higgins Simon Y W Ho Jan Salomonsen Karsten Skjodt Lee G Miles Jaime Gongora
Publish Date: 2013/11/20
Volume: 66, Issue: 1, Pages: 53-65
PDF Link

Abstract

The major histocompatibility complex MHC is a dynamic genomic region with an essential role in the adaptive immunity of jawed vertebrates The evolution of the MHC has been dominated by gene duplication and gene loss commonly known as the birthanddeath process Evolutionary studies of the MHC have mostly focused on model species However the investigation of this region in nonavian reptiles is still in its infancy To provide insights into the evolutionary mechanisms that have shaped the diversity of this region in the Order Crocodylia we investigated MHC class I exon 3 intron 3 and exon 4 across 20 species of the families Alligatoridae and Crocodilidae We generated 124 DNA sequences and identified 31 putative functional variants as well as 14 null variants Phylogenetic analyses revealed three gene groups all of which were present in Crocodilidae but only one in Alligatoridae Within these groups variants generally appear to cluster at the genus or family level rather than in speciesspecific groups In addition we found variation in gene copy number and some indication of interlocus recombination These results suggest that MHC class I in Crocodylia underwent independent events of gene duplication particularly in Crocodilidae These findings enhance our understanding of MHC class I evolution and provide a preliminary framework for comparative studies of other nonavian reptiles as well as diversity assessment within CrocodyliaWe thank Dr Travis Glenn Dr Kent Vliet Robert Godshalk Mitch Eaton and Dr Matthew Shirley who kindly provided us with many of the DNA samples included in this investigation We are grateful to Porosus Pty Ltd for providing the Australian saltwater and Johnstons crocodile samples We also thank Dr Camilla Whittington for copy editing an early draft of the manuscript

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Recent duplication and inter-locus gene conversion in major histocompatibility class II genes in a teleost, the three-spined stickleback
  2. A mutation in KIR3DS1 that results in truncation and lack of cell surface expression
  3. Ly49 genes in non-rodent mammals
  4. Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
  5. HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer
  6. A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01
  7. Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques ( Macaca fascicularis )
  8. Polymorphism and evolution in the constant region of the T-cell receptor beta chain in an advanced teleost fish
  9. Is there a role for mannan-binding lectin in the diagnosis of inflammatory bowel disease?
  10. Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters
  11. At least one YMHCI molecule in the chicken is alloimmunogenic and dynamically expressed on spleen cells during development
  12. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers
Search Result: