Genomewide association study identifies Emphasis

Authors: Chen Yang Wang Jie Yang Yanlong Guo Xuefeng Tan Aihua Gao Yong Lu Zheng Zhang Youjie Zhang Haiying Qin Xue Qin Min Mo Linjian Yang xiaobo Hu Yanling Mo Zengnan

Publish Date: 2012/08/03

Volume: 64, Issue: 10, Pages: 747-753

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Abstract

IgA is an important factor in our immune system There are many diseases associated with it such as IgA nephropathy IgA deficiency and so on In order to describe the relationship between the genes and the IgA level we performed a genomewide association study of serum IgA with 1999 healthy Chinese men in the first stage and replicated on an independent Chinese sample with 1496 subjects in the second stage Association between each SNP with IgA was estimated by multivariate linear regression analysis conditioned on age and smoke Haplotype analysis for the block around the top SNP was performed In the first stage one genomic locus was identified to be significantly associated with IgA The loci is TNFSF13 17p131 rs3803800 P = 626 × 10−8 In smokespecific analysis rs3803800 was approximately significantly associated with IgA levels in smokers P = 396 × 10−7 while no association was observed in nonsmokers P = 228 × 10−1 In addition we performed the haplotype analysis on chromosome 17 with the SNPs around rs3803800 Although the total P value for the haplotype did not acquire significant difference three haplotypes TGAG CACG and CACA reached significant P  005 In conclusion TNFSF13 could be a susceptible gene which was discovered having relationship with serum IgA level and smoke might be a factor infecting the IgA levelThis study was partially supported by grants from the National Natural Science Foundation of China 81060213 81060234 30945204 30360124 30260110 Key Program and University Talents Highland Innovation Team of Guangxi 2012012D003 GJR20114709 Chairman Science and Technology Fund and Tackle Program of Guangxi 111603 GKG12980030701 Guangxi Science Fund for Distinguished Young Scholars 2012GXNSFFA060009 Guangxi Provincial Department of Finance and Education 2009GJCJ150 intramural funding from FudanVARI Center for genetic Epidemiology and intramural funding from Fudan University Institute of Urology Guangxi Natural Science Foundation 2011GXNSFB018100The funders had no role in study design data collection and analysis decision to publish or preparation of the manuscript

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