Authors: D V Tsyganov A P Yakubov L D Konyushkin S I Firgang V V Semenov
Publish Date: 2008/09/20
Volume: 56, Issue: 12, Pages: 2460-2465
Abstract
A series of analogs of the natural mitostatic agent combretastatin were synthesized by the reaction of nitrile oxides with natural allylbenzenes such as myristicin apiol and dillapiol The 13dipolar cycloaddition reactions in allylic systems proceed regiospecifically The reactions with trans isomers of propenylbenzenes viz isomyristicin isoapiol and isodillapiol as dipolarophiles produce regioisomers
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