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Title of Journal: Cell Stress and Chaperones

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Abbravation: Cell Stress and Chaperones

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Springer Netherlands

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DOI

10.1016/j.aorn.2007.04.018

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1466-1268

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New candidate genes for heat resistance in Emphas

Authors: Louise Toft Jensen Morten Muhlig Nielsen Volker Loeschcke
Publish Date: 2008/02/14
Volume: 13, Issue: 2, Pages: 177-182
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Abstract

The cellular heat stress response is well studied in Drosophila in respect to the role of heat shock proteins Hsp Hsps are molecular chaperones highly expressed during and after exposure to numerous stress types Hsps are all regulated by a common transcription factor the heat shock factor HSF and it is known that HSF is controlling other so far uncharacterised heatresponsive genes In this study we investigate whether novel candidate genes for heat resistance identified by microarray experiments are regulated by HSF The microarray experiments recently identified several strongly upregulated genes in response to a short nonlethal heat treatment in Drosophila melanogaster To test whether or not a subset of these genes are HSFinduced we studied 11 currently unannotated genes using quantitative polymerase chain reaction on HSF mutant flies with a nonfunctional HSF at elevated temperatures We found indication of HSF regulation in most of the studied genes suggesting a role of these unknown genes in heat tolerance Surprisingly some of the genes seemed to be upregulated independent of HSF function The high induction in response to heat which mimics the expression profile of Hsps implies a role in the cellular heat response of these genes as wellWe thank Jesper Sørensen for assistance with the fly strains and Kamilla Pedersen Torsten Kristensen Cino Pertoldi and Pernille Sarup for helpful suggestions to the manuscript The study was supported by a center grant from the Natural Sciences Research Council and a grant from the Novo Nordisk Foundation to VL LTJ was supported by a stipend from the Faculty of Science University of Aarhus

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  2. A cell model to study different degrees of Hsp60 deficiency in HEK293 cells
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  10. Small heat shock proteins: big folding machines
  11. A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells
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