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Title of Journal: Cell Stress and Chaperones

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Abbravation: Cell Stress and Chaperones

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Springer Netherlands

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DOI

10.1016/0006-2952(91)90027-3

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1466-1268

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Dietinduced elevation of circulating HSP70 may tr

Authors: Fang Xie Rui Zhan LiCheng Yan JingBo Gong Yun Zhao Jing Ma LingJia Qian
Publish Date: 2016/07/19
Volume: 21, Issue: 5, Pages: 907-914
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Abstract

Although accumulating evidence indicates that heat shock protein 70 HSP70 could be secreted into plasma and its levels have been found to have an ambiguous association with atherosclerosis our knowledge for the exact role of circulating HSP70 in the development of atherosclerosis is still limited In the present study we report an adhesionpromoting effect of exogenous HSP70 and evaluate the potential involvement of elevated circulating HSP70 in the development of atherosclerosis Timedependent elevation of plasma HSP70 was found in dietinduced atherosclerotic rats whose effect was investigated through further in vitro experiments In rat aortic endothelial cell RAEC cultures exogenous HSP70 incubation neither produced cell injuries by itself nor had protective effects on cell injuries caused by OxLDL or homocysteine However exogenous HSP70 administration could lead to a higher adhesion rate between rat peripheral blood monocytes PBMCs and RAECs This adhesionpromoting effect appeared only when PBMCs rather than RAECs were pretreated with HSP70 incubation PBMCs in an HSP70 environment released more IL6 to supernatant which subsequently upregulated the expression of ICAM1 in RAECs These results indicate that the dietinduced elevation of circulating HSP70 could trigger cell adhesion with the help of IL6 as a mediator which provides a novel possible mechanism for understanding the role of circulating HSP70 in the pathogenesis of atherosclerosis

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