Journal Title
Title of Journal: Cell Stress and Chaperones
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Abbravation: Cell Stress and Chaperones
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Publisher
Springer Netherlands
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Authors: Balaraman Ganesan Rangasamy Anandan
Publish Date: 2009/03/18
Volume: 14, Issue: 6, Pages: 661-
Abstract
Myocardial infarction is one of the most common manifestations of cardiovascular disease In the present study we investigated the protective effect of betaine a potent lipotropic molecule on changes in the levels of lysosomal enzymes and lipid peroxidation in isoprenalineinduced myocardial infarction in Wistar rats an animal model of myocardial infarction in man Male albino Wistar rats were pretreated with betaine 250 mg/kg body weight daily for a period of 30 days After the treatment period isoprenaline 11 mg/100 g body weight was intraperitoneally administered to rats at intervals of 24 h for 2 days The activities of lysosomal enzymes βglucuronidase βgalactosidase βglucosidase and acid phosphatase were significantly p 005 increased in plasma with a concomitant decline in the activities of these enzymes in heart tissue of isoprenalineadministered rats Also the level of lipid peroxidation was higher in heart lysosomes of isoprenalineinjected rats Pretreatment with betaine daily for a period of 30 days to isoprenalineinduced rats prevented the changes in the activities of these lysosomal enzymes Oral treatment with betaine 250 mg/kg body weight to normal control rats did not show any significant effect in all the biochemical parameters studied Thus the results of our study show that betaine protects the lysosomal membrane against isoprenalineinduced myocardial infarction The observed effects might be due to the free radicalscavenging and membranestabilizing properties of betaine
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