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Title of Journal: Cell Stress and Chaperones

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Abbravation: Cell Stress and Chaperones

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Springer Netherlands

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1466-1268

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Tissuespecific upregulation of HSP72 in mice foll

Authors: Aminul Islam Preetha Abraham Christopher D Hapner Patricia A Deuster Yifan Chen
Publish Date: 2012/09/26
Volume: 18, Issue: 2, Pages: 215-222
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Abstract

Oxidative stress and cellular injury have been implicated in induction of HSP72 by alcohol We investigated the association between HSP72 induction and oxidative stress in mouse tissues following shortterm administration of high doses of alcohol and caffeine alone or in combination Adult male C57BL/6J mice were gavaged with vehicle alcohol ∼17 g/kg/day caffeine ∼44 mg/kg/day or alcohol plus caffeine once daily for ten consecutive days Upon completion of the treatments tissues were collected for structural and biochemical analyses Alcohol alone caused mild to moderate lesions in heart liver and gastrocnemius muscle Similar structural changes were observed following administration of alcohol and caffeine combined Alcohol administration also led to decreased glutathione levels in all three tissues and reduced plasma superoxide dismutase capacity In contrast alcohol and caffeine in combination reduced glutathione levels only in liver and gastrocnemius muscle and had no effect on plasma superoxide dismutase Significant elevations in HSP72 protein and mRNA and in HSF1 protein levels were noted only in liver by alcohol alone or in combination with caffeine No significant changes in morphology and HSP72 were detected in any tissues tested following administration of caffeine alone These results suggest that a redox mechanism is involved in the structural impairment caused by shortterm highdose alcohol Oxidative tissue injury by alcohol may not be associated with tissue HSP72 induction Induction of HSP72 in liver by alcohol is mediated at both the transcriptional and translational levelsWe consulted Dr Cara Olsen Department of Preventive Medicine and Biometrics Uniformed Services University of the Health Sciences USUHS for statistical analysis This work was supported by USUHS Grant R091EH and the Office of Naval Research Grant N0001411MP20025

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  2. A cell model to study different degrees of Hsp60 deficiency in HEK293 cells
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  5. Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage
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  7. Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats
  8. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF
  9. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana
  10. Small heat shock proteins: big folding machines
  11. A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells
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