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Title of Journal: Cell Stress and Chaperones

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Abbravation: Cell Stress and Chaperones

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Springer Netherlands

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DOI

10.1002/pca.1125

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1466-1268

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Involvement of molecular chaperones and the transc

Authors: Fariba Khodagholi Niloufar Ansari Mohsen Amini Solaleh Khoramian Tusi
Publish Date: 2012/01/04
Volume: 17, Issue: 4, Pages: 409-422
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Abstract

Much evidence supports that oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease Herein we studied the compensatory/adaptive mechanisms involved in 3thiomethyl56diphenyl124triazine and 3thiomethyl56dichlorophenyl124triazine neuroprotection We found that these compounds could counteract H2O2induced rupture of neurite outgrowth in differentiated PC12 cells In addition we found that pretreatment of cells with triazine derivatives could modulate the expression of heat shock proteins Hsp70 Hsp90 and Hsp32 in H2O2treated PC12 cells These compounds could also increase nuclear level of stress sensing transcription factor NFE2 related factor 2 which contributes to redox homeostasis and cell survival following stress As a result the elevated levels of glutamylcysteine synthetase glutathione peroxidase1 and glutathione as well as superoxide dismutase and catalase increased cellular antioxidant capacity Studying the relation between structure and activity of these compounds will pave the way for exploiting preventive and/or therapeutic strategies for the management of oxidative stressmediated disorders

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  2. Tissue-specific upregulation of HSP72 in mice following short-term administration of alcohol
  3. The P5 disulfide switch: taming the aging unfolded protein response
  4. Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats
  5. Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage
  6. Solar radiation stress in climbing snails: behavioural and intrinsic features define the Hsp70 level in natural populations of Xeropicta derbentina (Pulmonata)
  7. Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats
  8. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF
  9. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana
  10. Small heat shock proteins: big folding machines
  11. A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells
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