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Title of Journal: Cell Stress and Chaperones

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Abbravation: Cell Stress and Chaperones

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Springer Netherlands

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DOI

10.1016/0968-0004(86)90186-6

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1466-1268

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The P5 disulfide switch taming the aging unfolded

Authors: Akash Mathew
Publish Date: 2015/06/05
Volume: 20, Issue: 5, Pages: 743-751
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Abstract

Aging is a process that involves a complex interplay between different factors that affect the overall integrity of an organism LopezOtin et al 2013 The phenomenon of aging can be summarized as a cumulative effect of the breakdown of various cellular functions resulting in altered intracellular communication Dickey et al 2009 Fulop et al 2014 an increase in genomic instability Moskalev et al 2013 telomere attrition Harley et al 1990 epigenetic alterations Chambers et al 2007 loss of proteostasis BenZvi et al 2009 deregulated nutrient sensing Powers et al 2006 mitochondrial dysfunction Cadenas and Davies 2000 and loss of stem cell proliferation Oreffo et al 1998One of the more comprehensive theories regarding the underlying cause of the phenomenon of aging is the aptly named quality control theory or the QC theory of aging This theory postulates that aging is a concomitant breakdown of several QC systems Briefly this theory states

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  5. Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage
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  8. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF
  9. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana
  10. Small heat shock proteins: big folding machines
  11. A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells
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