Total antioxidant capacity and lipid peroxidation

Authors: Vaishali N Thorat Adinath N Suryakar Pradeep Naik Bipin M Tiwale

Publish Date: 2009/05/08

Volume: 24, Issue: 1, Pages: 102-104

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Abstract

Liver transplantation is an accepted therapy for chronic liver disease patients These patients generally have low levels of fat soluble vitamins which have important antioxidant roles Therefore this study was undertaken to investigate whether such patients had evidence of antioxidant depletion and increased lipid peroxidation before transplant and whether the subsequent ischemia and reperfusion encountered during liver transplantation have any effect on antioxidant levels and lipid peroxidation We assessed plasma total antioxidant capacity and serum lipid peroxide in 12 patients undergoing liver transplantation and equal numbers of healthy subjects We found that before reperfusion antioxidant levels were significantly decreased along with significantly elevated lipid peroxidation levels as compared with healthy controls P0001 On reperfusion of the liver graft further declined values of total antioxidant accompanied with highly elevated lipid peroxidation were seen than those of prereperfusion samples P0001 This data shows that patients undergoing liver transplant have lowered antioxidant defenses and evidence of free radical damage which compound the additional insult of reperfusion injury Therefore antioxidant therapy in these patients before transplantation may ameliorate the effects of reperfusion

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