ArsenicInduced Hepatic Toxicity and Its Attenuati

Authors: Manish K Singh Shailendra Dwivedi Suraj S Yadav Praveen Sharma Sanjay Khattri

Publish Date: 2013/06/15

Volume: 29, Issue: 1, Pages: 29-37

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Abstract

Arsenic a metalloid and environmental contaminated has been found to be associated with public health problems in the affected areas It is naturally occurred in groundwater and its accumulation in plant and animals leads to toxicity in several tissues most notably hepatic organ Arsenic exposures 3 mg/kg body weight/day for 30 days in mice exhibited increased arsenic and Zn levels in hepatocytes associated with enhanced oxidative stress in hepatocytes while there were no significantly changes were observed in Cu level An increase in the lipid peroxidation and decrease in the levels of reduced glutathione and activity of superoxide dismutase catalase and glutathione peroxidase were observed in arsenic treated mice as compared to controls Arsenic exposure in mice also caused a significant change in serum biomarkers in the SGOT SGPT and creatinine as compared to the controls There were no significant changes in the serum levels of total protein in these mice Coadministration of arsenic and fruit extract of amla 500 mg/kg body weight/day for 30 days caused a significant reduction of arsenic transference associated with significantly decreases hepatic arsenic levels and balanced the antioxidant enzyme and levels of serum hepatic enzymes like SGOT and SGPT The results of the present study clearly demonstrate the antioxidant property of amla that could be responsible for its protective efficacy in arsenic induced hepatic toxicityAuthors are thankful to the Department of Pharmacology King George’s Medical University Lucknow for providing research facilities and to the Indian Council of Medical Research ICMR New Delhi for providing financial assistance as Senior Research Fellow

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