Association of Prooxidant–Antioxidant Balance with

Authors: Niloofar Heshmati Shoaleh Shahgheibi Bahram Nikkhoo Sabrieh Amini Mohammad Abdi

Publish Date: 2016/08/31

Volume: 32, Issue: 3, Pages: 315-322

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Abstract

Polycystic ovarian syndrome is one of the most common hormonally leading cause infertility disorders The effect of oxidantantioxidant imbalance on disease progression has been studied in many disorders The present study was aimed to evaluate prooxidant–antioxidant balance PAB in patients with polycystic ovarian syndrome compared to healthy subjects We also studied the possible effect of treatment with available drugs on serum PAB In this case–control study 100 polycystic ovary syndrome PCOS patients and 100 healthy individuals were enrolled in the study The laboratory features of patients and controls like as serum LH and FSH concentration and hematological examinations were collected PAB was evaluated by a colorimetric method Serum PAB value was significantly higher before treatment compared to after treatment and healthy subjects PAB values were also higher in subjects with irregular menstrual cycle compared to normal subjects Our results represented that serum PAB values has an indirect significant correlation with serum LH concentration We also found that drugs regimen containing spironolactone effectively reduced the serum PAB values Our results showed that PCOS patients had increased level of PAB and treatment with spironolactone mainly decreases the level of serum PAB Our results indicate that the measurements of PAB may be used as a potential laboratory marker for assessment of PCOS patients

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