Total Serum Immunoglobulin E in Children with Asth

Authors: M Lama M Chatterjee T K Chaudhuri

Publish Date: 2012/08/17

Volume: 28, Issue: 2, Pages: 197-200

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Abstract

Immunoglobulin Ig E has been shown to be a major contributing factor for the development of bronchial hyperresponsiveness in asthma An elevation in serum IgE levels contributes to asthma and is considered a potent predictor of the development of asthma The objectives of the present study were to estimate the levels of total serum IgE in asthmatic and healthy control subjects and to investigate the relationship of various demographic and clinical characteristics with the total serum IgE level in asthmatics We measured the levels of total serum IgE using the ELISA kits AccuBind Monobind Inc USA The relevant demographic and clinical data were obtained using the questionnaire The results showed that asthmatic children had significantly elevated level of total serum IgE compared to that of the healthy controls The levels of total IgE and IL4 in sera of 44 asthmatic children showed a significant positive correlation Total serum IgE 150 IU/mL was found to be significantly associated with the age exposure to cigarette smoke and raised eosinophil count in asthmatic children In conclusion the elevated level of total serum IgE may demonstrate the allergic etiology of asthma in the subjects studiedAuthors are thankful to the University Grants Commission UGC New Delhi for the financial support provided to carry out this study The authors are indebted to all the participants and their parents for their participation and cooperation Further authors would like to extend sincere thanks to medical officers of Pediatric Department North Bengal Medical College and Hospital Siliguri for their kind help throughout the study

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