Maternal Leptin Adiponectin Resistin Visfatin a

Authors: Amani F H Noureldeen Safaa Y Qusti Madeha N Alseeni Maram H Bagais

Publish Date: 2013/10/29

Volume: 29, Issue: 4, Pages: 462-470

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Abstract

Gestational diabetes mellitus GDM is a common medical complication associated with pregnancy The present study evaluates the changes in maternal adipocytokines leptin adiponectin resistin visfatin and tumor necrosis factoralpha TNFα in pregnancy complicated with GDM compared to normal pregnancy at 2nd and 3rd trimesters The study included total number of 142 pregnant women classified into 4 groups normal pregnancy n = 33 and pregnancy with GDM n = 24 both at 2nd trimester and normal pregnancy n = 38 and GDM n = 47 at 3rd trimester Both GDM groups were significantly presented with elevated body mass index fasting blood sugar and abnormal oral glucose tolerance test compared to their matched control Results indicated reduction in maternal serum leptin and adiponectin in GDM compared to normal pregnancy at 3rd trimester Elevated resistin and TNFα were evident among pregnancy complicated with GDM at both tested trimesters On the other hand significant elevation in maternal visfatin was noted between GDM and matched control at 2nd trimester only Significant increase in maternal leptin and visfatin and resistin was noted by advances in gestational period in healthy pregnancy On the other hand reduced adiponectin and elevated visfatin mean values were noticed in GDM at 3rd compared to 2nd trimester It could be concluded that increased insulin resistance accompanies GDM is associated with suppressed leptin and adiponectin and increased resistin and TNFα which might suggest their involvement in the development of GDMThe authors are grateful to the Deanship of Scientific Research King Abdul Aziz University Jeddah Saudi Arabia for the generous financial support of the Project No 17026/430 The authors also thank Prof Hassan S Abduljabbar Consultant and Professor of Obstetrics and Gynecology King Abdul Aziz University Hospital and Dr Nabeela Y Qusti Senior Specialist in Maternity and Children Hospital Jeddah for their assistance in diagnosing and collecting samples

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