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Title of Journal: Chin Ger J Clin Oncol

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Abbravation: The Chinese-German Journal of Clinical Oncology

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Springer-Verlag

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DOI

10.1007/bf01322701

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1613-9089

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The effects and mechanism of action of Prunella vu

Authors: Changying Chen Gang Wu Mingzhi Zhang
Publish Date: 2009/07/23
Volume: 8, Issue: 7, Pages: 426-429
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Abstract

Jurkat cells were cultivated with different concentrations of the extract from Prunella vulgaris L The MTT assay and flow cytometry were employed to determine the cells’ proliferation inhibition ratio and the apoptosis rates respectively Agarose gel electrophoresis was used to observe cellular DNA fragmentation and western blotting was used to observe changes in Bcl2 and Bax protein expressionThe Prunella vulgaris L extract remarkably inhibited the proliferation of Jurkat cells This inhibition exhibited dose dependence with an IC50 of 2023 ± 031 μg/mL Agarose gel electrophoresis showed that the apoptosis strap became wider and brighter and flow cytometry showed that the apoptosis rate increased in a concentrationdependent manner Western blotting showed that Bcl2 protein was downregulated and Bax protein was upregulated during apoptosis


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