Rupture of hepatocellular carcinoma following tran

Authors: Ping Sun Zifang Song Qinggang Hu Jun Xiong Shaobo Hu Ruiqing He Qichang Zheng

Publish Date: 2013/02/12

Volume: 12, Issue: 2, Pages: 76-82

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Abstract

Rupture of hepatocellular carcinoma HCC following transarterial embolization/chemoembolization TAE/TACE is a rare but lifethreatening complication The aim of the study was to explore the incidence risk factors clinical characteristics treatment and outcomes of this complicationOur search yielded 32 cases of ruptured HCC after TAE/TACE The overall incidences were 045 per patient and 021 per session The mean age of the patients was 574 years range 28–90 years n = 26 No of cases with available information Males accounted for 81 of cases 21/26 The 50 of the cases had histories of primary hypertension diabetes or peripheral artery disease 6/12 Mean diameter of the tumors was 114 cm range 3–20 cm n = 27 The 100 of cases had superficial or exophytic tumors 23/23 Portal vein thrombosis was presented in 615 of patients 8/13 The median interval between TAE/TACE and rupture was 2 days range 0 hour — 30 days n = 31 Management choices included emergency TAE surgery and conservative treatment The overall median survival time was 7 days n = 19Rupture of HCC following TAE/TACE is relatively rare but potentially lifethreatening The management is difficult and prognosis is poor Large tumor size superficial or exophytic tumors as well as portal vein thrombosis and comorbidities such as primary hypertension diabetes or peripheral artery disease may be predisposing factors for rupture

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