The relationship between the expression of hK6 in

Authors: Chengjin Hu Fang Zhang Kuixiang Chen Yingjian Chen

Publish Date: 2010/01/28

Volume: 9, Issue: 1, Pages: 40-43

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Abstract

Through immunohistochemistry to examine the expression of hK6 in 19 cases with benign 11 cases with borderline and 45 cases with malignant ovarian neoplasms and statistically analyzed whether the expression of hK6 correlated with the clinicopathologic variables and prognosis in patients with ovarian cancerThe positive rate of hK6 in ovarian cancer tissues 600 was significantly higher than that in the benign 158 and borderline 273 ovarian neoplasm tissues P 001 The expression of hK6 in lowgrade ovarian cancer tissues was higher than that in highgrade 684 vs 143 P 005 hK6 in latestage stage III was more frequently expressed than that in earlystage stage I or II 767 vs 267 P 001 and it significantly higher in ovarian carcinomas with lymph node metastases than those without lymph node metastases 778 vs 333 P 001 moreover the expression of hK6 in the cancer tissues that the patients died or their pathogenetic condition recurred or their tumor metastasized within 3 years after surgery was higher 750 than that in the cancer tissues that the pathogenetic condition of the patients was stable 429 P 005The expression of hK6 in ovarian cancer tissues was higher than that in the benign and borderline ovarian neoplasm tissues and high hK6 expression correlated with latestage lowgrade node metastasis and poor prognosis of patients hK6 could potentially be a novel tumor marker for ovarian cancer that can predict the prognosis of the patients

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