Authors: Philippe Sèbe Christelle Doucet JeanNicolas Cornu Calin Ciofu Pierre Costa Sixtina Gil Diez de Medina Christian Pinset Francois Haab
Publish Date: 2010/09/07
Volume: 22, Issue: 2, Pages: 183-189
Abstract
We conducted an open prospective study on 12 women presenting severe SUI with fixed urethra after previous failed surgical management Patients underwent intrasphincteric injections of autologous progenitor muscular cells isolated from a biopsy of deltoid muscle Primary endpoint focused on safety measurement of Q max variation after 3 months Secondary endpoints assessed side effects and efficacyNo variation was diagnosed on Q max measurements Efficacy data show that three of 12 patients are dry at 12 months seven other patients are improved on pad test but not on voiding diary and two patients were slightly worsened by the procedure Quality of life was improved in half of patients
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